Beta Sigma
Beta Sigma
 |
 |
Cooking With Alpha Tau Xi Beta Sigma Phi Cookbook Texas |  |
 |
US $5.99 | 29d 17h 32m |
 |
The Beta Sigma Phi IntSave Win 1 2 Cookbook 1 2Craft | |
|
US $7.99 | 28d 15h 45m |
 |
The BETA SIGMA PHI FONDUE BUFFET COOKBOOK 1972 | |
|
US $4.54 | 28d 11h 41m |
 |
Silver Anniversary Cookbook Beta Sigma Phi 1956 | |
|
US $12.95 | 27d 12h 20m |
 |
Beta Sigma Phi SAVE AND WIN Cookbook Craft Book | |
|
US $4.99 | 26d 23h 52m |
 |
The Millennium Cookbook Beta Sigma Phi | |
|
US $1.50 | 26d 14h 25m |
 |
Beta Sigma Phi International Party Book 1973 | |
|
US $12.99 | 26d 10h |
 |
Bicentennial Recipes Limited Edition Cookbook | |
|
US $2.97 | 26d 3h 53m |
 |
Lot 10 Cookbooks Herbs Chinese Festival Regional WOW | |
|
US $12.74 | 25d 15h 35m |
 |
The Beta Sigma Phi Int Meats Cookbook 2000 Rec382p68 | |
|
US $14.99 | 25d 15h 3m |
 |
CookBook Beta Sigma Phi Montgomery Alabama Vintage Old | |
|
US $29.98 | 25d 10h 22m |
 |
1971 Beta Sigma Phi Holiday Cookbook Cookbook Cook Book | |
|
US $10.80 | 25d 10h 22m |
 |
FONDUE BUFFET Cookbook by Beta Sigma Phi Intl | |
|
US $4.00 | 25d 9h 31m |
 |
Simple Celebrations Cookbook Beta Sigma Phi 222p99 | |
|
US $12.99 | 25d 5h 51m |
 |
Recipes from the World of Beta Sigma Phi Cookbook | |
|
US $5.99 | 24d 10h 32m |
 |
Phi Beta Sigma Greek Throw Blanket Rug Afghan New Gift Sale Price: $44.99  |
|
Phi Beta Sigma Fraternity Sorority Greek Cotton Tapestry Throw Blanket Rug Afghan. This beautiful throw measures 48 X 60 inches, and is proudly made in the USA. Great decoration for you home, excellent to use to keep warm, fold on bed, use as wall hanging, picnic / beach blanket etc... |
 |
Trico 37-170 Winter Wiper Blade - 17" List Price: $16.05 Sale Price: $7.62 |
|
Trico Winter Wiper Blade is designed to work great even in winter conditions. It is made from strong durable metal which is encased in a protective boot to prevent snow clogs. This wiper blade features a precision cut natural rubber wiping element and ensures easy installation. |
 |
Soul Steppin List Price: $5.98 Sale Price: $2.59 Average Rating:  |
|
Take a trip with the Brothers of Phi Beta Sigma Fraternity, Incorporated and their national step team from the University of Houston as they travel to Philadelphia to partake in a step show competition... |
 |
There Was A Spirit List Price: $17.95 Average Rating: |
|
When the non-violent Civil Rights movement came to a close and the Black Power movement emerged, a generation of leaders less tolerant and more aggressive took the stage. A young, brilliant Black woman at the top of her class, Najwa K... |
 |
Marlon Garci 100% Woven Silk Blue & White Stripe Self-Tie Bow Tie - Kentucky, Duke, Phi Beta Sigma Sale Price: $13.99 Average Rating:  |
|
Show your University of Kentucky, Duke University, Indiana State University, Middle Tennessee State University and Phi Beta Sigma support with this beautiful tie. This tie is perfect for showing your support at games and events!! Specifications are: 2... |
 |
Baywood Beta-s, 90 Tablets List Price: $18.95 Sale Price: $14.54 |
|
What is Beta-sitosterol? Beta-sitosterol is a plant sterol similar in structure to cholesterol, found naturally in fruits, vegetables, beans (especially soy), nuts, and seeds... |
Valorphin and Related Peptide
Definition
Valorphin, an endogenous opioid-like hemoglobin fragment is a semisynthetic derivative of dihydrovaltrate1. It may be the precursor of a smaller peptide with more opiate-like activity named hemorphin.
Discovery
Valorphin was isolated from bovine hypothalamic tissue and purified by solid phase extraction and several reversed-phase HPLC steps.
Related Peptide
Leu-Valorphin-Arg peptide corresponds to the sequence (32-40) of the β-,δ-,γ-, and ε-chains of human hemoglobin. The sequence of Leu-Valorphin-Arg peptide is H-Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-OH. It shows binding affinity for µ- and sigma-opioid receptors and has opioid activity in the GPI bioassay. It is found in large amounts in the pituitary and seems to be present in the circulation to a much lesser degree. In view of its high stability towards the membrane-bound lung enzymes and its strong inhibitory action on ACE activity, it appears to be the most potent of the hemorphin-related peptides assayed.
Structural Characteristics
The amino acid sequence of the purified peptide was determined by Edman degradation to be Val-Val-Tyr-Pro-Trp-Thr-Gln. This was confirmed by comparison of its chromatographic behavior with that of the synthetic peptide, and mass spectrometric analysis resulted in a mass identical to the calculated mass for valrophin peptide. This heptapeptide shows homology with residues 32-38 of the beta-chain of bovine hemoglobin2. Molecular weight, molecular formula of valrophin is 351.867 g/mol and C19H26ClNO3 respectively.
Mode of Action
Valorphin is a novel chemical entity, structurally not related to known opioids, which interacts preferentially with opiate mu-receptors.In vitro binding studies using brain homogenates from rat and guinea-pig indicate a preference for the μ-receptor site. Valorphin on application to cultured cerebellar Purkinje cells inhibited the spontaneous firing, similar to the effect seen with morphine.
Functions
Valorphin, an endogenous opioid-like hemoglobin fragment, is cytotoxic for L929 and K562 tumor cells in 10-7-10-13 M concentration range. Because cytolytic effects induced by valorphin in K562 cells are inhibited by naloxone, opioid receptors should be involved in induction of valorphin-mediated tumor cell death. Three distinct cytolytic processes, differing in the onset time and the development time, take place with K562 cells within 10-18 h of incubation with valorphin. All three processes are not associated with apoptotic mechanism of cell death.
Valorphin suppressed the proliferation of tumour cells by 25%-95%, depending on the cell line. The maximal valorphin activity was detected in transformed cells of fibroblastic (L929) and epithelial (MCF-7) origin, transformed haematopoietic cells (K562, HL-60) being less sensitive. In normal cells, valorphin activity was several fold lower (10%-15%). A study of the dynamics of cell proliferation in L929 cells using a visual cell count and flow cytometry showed that valorphin induced reversible and relatively short (24 h) S-phase arrest of cell proliferation, accompanied by a reversible increase of cell size. The proliferation delay was followed by a comparatively long period of reversible resistance of the cells to the peptide (96 h) when the cells are dividing at normal rate. The same dynamics were demonstrated for A549, MCF-7 and primary murine breast carcinoma cells3.
References
1.Blishchenko EYu, Mernenko OA, Mirkina II, Satpaev DK, Ivanov VS, Tchikin LD, Ostrovsky AG, Karelin AA, Ivanov VT (1997). Tumor cell cytolysis mediated by valorphin, an opioid-like fragment of hemoglobin beta-chain. Peptides., 18(1):79-85.
2.Erchegyi J, Kastin AJ, Zadina JE, Qiu XD (1992). Isolation of a heptapeptide Val-Val-Tyr-Pro-Trp-Thr-Gln (valorphin) with some opiate activity. Int J Pept Protein Res., 39(6):477-484.
3.Blishchenko E, Sazonova O, Surovoy A, Khaidukov S, Sheikine Y, Sokolov D, Freidlin I, Philippova M, Vass A, Karelin A, Ivanov V (2002). Antiproliferative action of valorphin in cell cultures. J Pept Sci., 8(8):438-452.
About the Author
Bio-Synthesis Inc. a leading provider for Custom Antibody, Custom Peptide Synthesis, Custom siRNA Synthesis, Organic Laboratory Technique, Antibiotic Peptides.
Brothers of Phi Beta Sigma can you please answer this?
whats G.O.M.A.B....no disrespect to your frat. im just really curious!!
answers are anonymous C'mon!!
HAPPY FOUNDERS DAY!!!!! <3..
Check out the web site
Phi Beta Sigma - Zeta Zeta Chapter
Mary C. Fulford
TAYLOR MILL - Mary C. Fulford, 81, of Hamilton, Ohio, formerly of Taylor Mill, died Wednesday, June 23, at her home.